Can organisms build up a resistance to Chlorine Dioxide?

No. Chlorine dioxide as a disinfectant has the advantage that it directly reacts with the cell wall of micro-organisms. This reaction is not dependent on reaction time or concentration. In contrast to non-oxidizing disinfectants, chlorine dioxide kills micro-organisms even when they are inactive.

Therefore the chlorine dioxide concentration needed to effectively kill micro-organisms is lower than non-oxidising disinfectant concentrations. Micro-organisms cannot built up any resistance against chlorine dioxide.

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